Abstract: Objective  To investigate mutations of gene epidermal growth factor receptor (EGFR) in the patients of non-small cell lung cancer (NSCLC) who were Guangxi Zhuang nationality. Methods 163 cases of NSCLC tissue were enrolled in this study. Mutations  of EGFR exons 18，19，20 and 21 were detected by amplification refractory mutation system (ARMS). The relation between EGFR mutation and clinical characters were analyzed，and they were compared with the reported data from other eight domestic regions. Results Mutations were found in 73 cases，with an incidence of 44.8% which was significantly higher than other eight domestic regions (30.0%，P＜0.05).The mutations were mainly in exon 19 and 21，each of them accounted for 38.4% of total.Mutations in adenocarcinoma and adenosquamous carcinoma accounted for 80.8% of total.Mutation rate in female (57.7%) was significantly higher than that in male (38.7%). Conclusions  Incidence of EGFR mutation in NSCLC patient with Zhuang nationality is higher than that in other regions of China. Mutations in exons 19 and 21 are more common. Female patient，patients with adenocarcinoma or adenosquamous carcinoma may be the appropriate crowd to be treated with EGFR tyrosine kinase inhibitor.

Key words: Epidermal growth factor receptor, Non-small cell lung cancer, Gene mutation